WEDNESDAY, JANUARY 6, 2010
D225E and D225N H1N1 RBD Changes in Turkey
The Refik Saydam National Public Health Agency has released 29 HA sequences from Ankara, Turkey. Several were partial sequences, but 26 covered the receptor binding domain and 8 had D225E (see list below), while one had D225N, A/Ankara/26/2009.
The outcomes of these patients were not given but media reports have described a rapid in increase in H1N1 fatalities in Turkey.
A large number of HA sequences with D225E has been published from Spain, and recently released GISAID sequences from Sweden and the UK also haveD225E, including three fatal cases from Sweden.
The prior reports of D225G and D225N associations with fatal cases has raised concerns that changes at position 225 could alter tissue tropism or aid in immune escape, leading to more severe and fatal cases.
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